anyone taking a GLP-1 ?

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davdev@reddit

Been on zepboubd for a few years. Lost 60lbs and relatively zero side effects after the first few weeks. And even those were mostly just minor indigestion.

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I went through almost all of them until I got to Mounjaro, the first year that it was available. The company was providing $25 coupons to anyone with a prescription. That ended after the first year it was out. After that, you had to have diabetes in order to qualify on insurance, which I don’t have. It was a pity because I had the best weight loss with the least side effects. Several frustrating years later, and last summer I finally got approved for Zepbound, the weight loss version of Mounjaro. Yes, all of these have side effects. The worst for me has been the GERD, especially at night — we’re talking waking up and rushing to the bathroom to painfully retch and vomit into the toilet. My doctor prescribed 40mg Pepcid to take every night, and that knocked it right out. To the point that I don’t even need it unless I have a dose increase.

KingPabloo@reddit

Exactly. My friend is on it and lost weight, but part of that has been lean muscle loss and bone density, she now has osteoporosis as result.

52 soon, and started Zepbound 6 months ago. It's been fantastic so far. My wife tried it first and has lost over 100 pounds in 2 years. It's given her her life back!

For me, I've lost 30 pounds in 6 months, slow and steady. I still enjoy food, still get hungry when I'm actually hungry, and actually feel full and done at the end of a normal size (not American restaurant-size) meal. Previous attempts have included stress and suffering, Optavia (a very-low-calorie diet sold through a pyramid scheme), Keto, and probably a few others I can't think of right now. They all worked, but they weren't sustainable for me. Keto was probably the closest to not feeling deprived all the time, but even then, I started to burn out on it. I missed being able to enjoy fresh fruit and other carbohydrates.

With all of them, I regained the weight back to roughly my starting point -- or higher. The difference with the GLP-1 drug is that I don't feel like I'm forcing a restriction on myself. Instead, my body is just saying "you're good" at a normal point. I can comfortably eat a reasonable meal, and I don't have the drive to snack all all the time. It's nice.

Based on everything I've read, I expect this to be a lifelong medication. My insurance won't cover it, so I'm paying the $499/mo. Yeah, it hurts, but I look at it like a subscription to a healthier and longer life, and I'll make other cuts as needed. (And hopefully the price will continue to drop -- it was $650/mo not too long ago.) At the same time, my blood pressure and bloodwork numbers are improving, and I'm about to stop my BP medicine because it's no longer needed.

So, respectfully, most obese folks have tried diet and exercise for years—some for their entire lives. It’s not about steps or carbs.

Obesity is a symptom of a chronic medical condition and has zero to do with willpower.

This is like my experience. I’m just getting to go on maintenance soon too.

OP, do it. I wish I did it sooner. It levels the playing field for not only people with historically low metabolism and now menopause. Do. It. If you have side effects, stop taking or switch to something else.

Who cares if you don’t do it the “natural way.” Your health matters the most.

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goingloopy@reddit

Plus, we all know the natural way doesn’t work. If it did, there would be no multibillion dollar diet industry. To me, the effectiveness of GLPs proves there’s a difference in how people’s brains are wired. It also tends to make people cut down or quit drinking, smoking, or other addictive behaviors.

It’s not cheating. And even if it is, IDGAF.

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Times-New-WHOA_man@reddit

Juon_Kahvia@reddit

Been on Wegovy for 2 years. Weight loss has been meh, about 10%, so eh.

But!

Cured my severe obstructive sleep apnoea. I havent needed my CPAP for 6 months now and getting best sleep of my life. And no, its not related to the weight loss, I was at a lower weight when diagnosed with sleep apnoea.

Also, food noise is gone. I can eat small amounts and be content, and not have that unrelenting "you are starving and will DIE, find food NOW!" demon screaming and clawing at me 24/7.

Its not cheap but I have energy and am more active and social.

Killed my interest in drinking alcohol though, like it flipped the switch in my brain that is responsible for sorting things into food, not-food, and poison catergories.

Wouldnt be suprised if one day Wegovy etc gets used as an off-label treatment tool for addiction.

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RedHeadedStepDevil@reddit

65+ lbs down so far. Started on Zepbound during the shortage two years ago and loved it. Had to briefly switch to Wegovy when I couldn’t physically get zepbound, and had the nausea. Switched back to Zepbound. Insurance was a PITA every single time and they stoped covering it almost a year ago, so I switched to compounded tirzepatide and it’s been a very good experience for me.

Soon after I started a GLP-1, my A1C which had been one point from diabetes, dropped into the normal range where it’s been ever since. My arthritis symptoms went away, so I was able to stop those meds. My BP also dropped into normal range, so those meds are gone. (All under the eye of my PCP.) My IBS symptoms also went away, so I can eat healthy foods (like fruits and vegetables) and I no longer live in chronic pain. I walk several miles every day.

I recommend GLP-1 to everyone I meet. Several people I know are on them and by far and large, have had an amazing experience with them. I will be on them for the rest of my life—which bothered me at first—but it’s about the quality of my life now. I’m not at my goal weight (I’d like to lose another 20#), but am healthy and can live at the weight I am now. (But only with the glp1–studies show I’d gain the weight back if I stopped them.)

There are several GLP-1 subs on Reddit and I’d encourage you to explore them. The ones on compounded tirzepatide saved my life when insurance coverage ended. I’d never have been able to pay out of pocket for brand.

I hate to say any drug is a miracle drug, but the GLP-1 meds have been for me.

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R5Jockey@reddit

This is what’s wild to me about GLP-1s. With all the health problems they actually solve (including reducing the risk of many others) I can’t understand why insurance companies aren’t trying to get everyone on them instead of fighting to not pay for them. Surely it’s cheaper to pay for one drug than numerous others and all the other costs eventually obesity brings.

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RedHeadedStepDevil@reddit

I agree 100%. It addresses and prevents a whole host of medical issues—diabetes, heart disease, Alzheimer’s. There are studies underway on its impact on alcoholism and more.

It also significantly decreased my rates with sleep apnea to almost zero (and this was before I lost 65#, so it wasn’t solely because of weight loss).

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Entiox@reddit

I was on Ozempic, then in March it nearly killed me. I had taken my first injection at the highest dose and was OK after the first could of days, just the usual amount of nausea and vomiting from taking it. Then the vomiting wouldn't stop and was like a fire hose. I ended up in the hospital for five days with severe dehydration that also caused my blood to thicken and kick me into diabetic ketoacidosis so I basically became acidic and started slowly dissolving myself from the inside. It was awful, the first the days in the hospital I was basically in a haze and barely coherent. I know people who have been taking them with no problems, but I certainly can't take it anymore.

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Seamusjamesl@reddit

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-Granby-@reddit

Another reason it's a no for me.

Possible facial mass loss? Nah, I'm good.

Diet and exercise has worked since forever. It's just not easy and it is slow. I'd rather go with that though than get the Zempi look and have my bones get all fucked up.

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marshdd@reddit

I exercise 1-3 hours a day in addition to taking Zepbound. How's that easy?

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-Granby-@reddit

I said diet and exercise is not easy.

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marshdd@reddit

No GLP face for me, down 175

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Trelin21@reddit

That’s just weight loss. And when you get older, skin don’t return as easily.

infinite_awkward@reddit

Be very, very cautious and hyper aware about your body’s performance. Monitor how your bowels function and communicate with your doctor about changes outside the expected norm.

Some people use them with success yet I personally know three people who had abdominal surgeries due to the side effects (one needed an illiostomy and had to wear a bag, 4 surgeries in total).

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AZJHawk@reddit

I’ve been on Zepbound for about a month. I’m also aiming to lose 40-50 pounds. I’ve been overweight since my 29s except for a brief stint in my mid thirties when I trained for and ran a half marathon. My weight has been fairly steady though.

It’s weird. It has definitely curbed my appetite. I have to force myself to eat for the first two or three days after each injection. I would actually prefer not to eat during that period because it doesn’t feel great to eat, but you don’t want your metabolism to crash. I drink a lot of protein shakes and small amounts of fiber and protein rich foods to maintain muscle and to stay regular. Even by the end of the week I don’t really feel hungry at all. I’ve dropped ten pounds in a month.

No. I still enjoy most foods. I just eat less. The one exception is greasy food. I used to love a greasy fast food meal. Now, the idea of them makes me a bit nauseous. I took a bite out of a burger last week, and immediately felt sick.

I still love a good meal, though. I just don’t need very much to fill me up. I tend to go for protein-heavy foods, but I can and do still enjoy carbs in moderation.

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Impossible_Storm_427@reddit

Yeah. Started in early December and lost 30 pounds. I used a compounded form of tirzepatide injection. The first month was a little rough with a lot of nausea but didn’t interfere with my everyday life too much and I took an anti nausea medication. Sometimes I would have stomach pains. But I also have had lifelong digestive issues so that could have been from my usual stuff.

I highly recommend. I’ve read several studies to understand the science and it has literally removed the age-induced hormonal barriers that we have all faced that prevent our bodies from synthesizing our food and functioning properly.

You could even peek at the various glp-1 subs on here to read about their experiences and success stories. It’s less about the visual results and more about the health gains that were out of reach for so long. Truly remarkable.

I took semaglutide for a little over a year and just switched to tirzepatide last month.

I am female, about 5’3” (shrank an inch and a half 😡). I’ve struggled with having no shut off valve all my life, and switched between binge drinking and eating too much. So thinner (but overweight) while drinking then fatter during sober years. Highest weight was 245 when I had gastric bypass around 24 years ago. I lost 100 pounds then and kept it off for a long time but gradually gained most back.

I started at 220 pounds when I first took the GLP1 and just weighed in at 135. That’s the lowest I’ve seen since high school. Also the meds are being shown to help with alcohol use too! My last drink (after a one-night relapse) was 2 years ago this month. I have no desire to drink.

I did not have the GI upset some experience while on Wegovy. Like online reviews, people tend to write about their negative experiences so please don’t think everyone is miserable while taking it!

I switched to Mounjaro last month because I was feeling more anhedonia and my doc and I decided to try this because the side effects are known to more minimal for most, and it’s more effective for most.

I haven’t had the food noise taken away completely, but already one month in I do see a difference. I am used to wanting something sweet every night, and have allowed myself something small but now have had a box of cookies left unopened because I just didn’t want them.

The meds are not magic and I do have to make good choices with what I eat. But I am able to eat in a much more sustainable way, having some foods that I want sometimes and not depriving myself.

I have been on Ozempic for a little over a year. Lost 100 pounds so far and no side effects* Also it's MUCH cheaper than all the groceries I was buying. I was borderline diabetic and now I am no longer, I was able to get off all diabetic drugs except Ozempic and the Doc kept me on that because of the weight loss, otherwise I would be off that as well. It makes me not hungry. At all. I can eat if I go out to dinner but I do it for the novelty because I am not hungry. I did have to learn to control my eating triggers. Sit down to watch a movie and the first thing I did for years was arrange my snacks. Now I barely have any snacks and they are not the junk I was eating. Nuts and jerky are my snacks because on this kind of drug you need high protein.

In 2 years I have lost 175 pounds, the longest I've ever been able to maintain healthy eating habits. Anyone that plans on saying well you could just try harder, have some discipline. Mind your own business.

Two years, pretty much zero negative effects. I no longer have constant, food thoughts. They used to be constant even in sleep.

Am I on it for life, possibly, but that's also true for seizure meds. No one is telling me to stop those.

Stop reading the click bait articles. They are there to be salacious. Also many of them are from people literally overdosing on the medication in order to try and lose faster.

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North-Bit-7411@reddit

This. I just read this after writing something similar above.

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Squibit314@reddit

I’m on zepbound too. It’s been great! It’s been a year and down 95 lbs.

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hoffmancorey81@reddit

I lost 50ish lbs in the first year on the 2.5 mg, just upped to 5mg due to food noise coming back. It is a life saver for sure.

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w3woody@reddit

I managed to finally get my weight under control starting a year ago by getting a Stelo CGM and monitoring which foods caused blood sugar spikes. I then tracked my diet to the gram using Cronometer, and modified my diet to (a) reduce carbohydrates (which caused blood sugar spikes which then caused me to be hungry in the afternoon, leading to overeating), and thus, (b) reduce my caloric intake so I could sustain a 1 pound a week weight loss diet.

A year later I dropped 65 pounds, from 249 to 184. That put my BMI to 26.5, which I've decided is 'good enough.'

I also started going to the gym regularly and bike riding regularly, working out at least 6 days a week, an hour a day, on a fitness routine that emphasizes 'Zone 2' training to improve my heart fitness, as well as adding resistance training to my workout towards the end. (At the gym, you actually gain weight; you lose weight at the kitchen.)

But it also involved a bit of 'hypervigilance' in my diet; I'm now using a gram-accurate food scale to weigh most of my ingredients. For some things I have a scale designed to weigh jewelry (so accurate to 0.01 grams) to weigh some ingredients.

All of this, and I feel much better than I have in decades.

Everyone thinks I took Ozempic.

I try to explain all of what I did--and no, they think I'm covering for taking Ozempic. (My health care plan doesn't cover it and I'm too cheap to pay the--what, $600/month for it?)

It's exhausting, to be honest.

At some point I may suggest to the next person who thinks I took Ozempic that cancer also causes weight loss.

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superthighheater3000@reddit

I’m 46m and have taken both semaglutide and tirzepatide. 5’10” and started about 230lbs.

Semaglutide worked well for the first few months and I lost about 25lbs. After that it really didn’t do much for me and my weight started creeping back up. I didn’t have any gastrointestinal side effects, but did notice that I had a little brain fog on the day that I took it. I did the shot 1x weekly, though for a period was doing 2x weekly at a half dose each time. After a few months I was back to my starting weight.

To combat the brain fog, I started taking the shot in the evening and that’s helped. I don’t experience the brain fog and still have had no other side effects.

I recently switched to Tirzepatide and at the initial dosage did not have any impact on hunger or weight loss. About two weeks ago I got the go-ahead to increase the dosage and since have lost about 5lbs and notice a significant decrease in food noise. No side effects, though I’ve only taken the dose in the evenings so may be sleeping through the worst of them.

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RedHeadedStepDevil@reddit

Did you move up in your dose at all??

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110 pounds off with Tirzepatide, went from 320 to 210. Gave me my life back.

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ibringstharuckus@reddit

Happy for you.

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angelaelle@reddit

Exercise and putting down the fork works for me. I would be too concerned about bad long term effects that will start showing up in a few years. That stuff makes people look like melted candles when they get thin because of the fast weight loss.

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Trelin21@reddit

My belly is so wrinkly, but that’s fine by me. I spent over 40 years stretching this skin suit, will take a lil work to tailor it back into shape.

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Glad_Nobody6992@reddit

Weight loss can cause saggy skin. It’s not the medications, it’s fast weight loss which can occur with any method.

And because something works for you that doesn’t mean it works for everyone. If it did, everyone would be thin. Calories in /calories out is obviously a factor but there is a lot more to it and not a simple matter of “willpower” for many.

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Magerimoje@reddit

My husband started on ozembic for his diabetes, and it really helped his blood sugar, and he was losing weight.

He was having pretty severe nausea for about 24 hours after taking each shot (it's once a week) so his doc switched him to Zepbound instead, and that's also controlling his blood glucose levels, helping him lose weight, without any side effects.

His appetize is lower, so instead of eating the larger portions of food he had been eating before going on a GLP-1, he's eating much smaller portions. He's still eating all the same types of food he's always eaten, he's not exercising (he can't due to severe issues with his knees and back - he's a disabled veteran).

Even with eating the same exact foods (just less) and not exercising, he's dropped about 50 pounds in the past 9 months. His BMI went from 41 to 32 so far.

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Trelin21@reddit

Same here, my A1C hit 5.9 after four months of mounjaro. The glp1/gip effect is phenomenal, and quite literally a life saver.

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BigDawg264@reddit

140lbs off in the last 16 months on Zepbound/tirzepatide. Lost the first 92 myself, but I went 2 months and couldn’t lose another pound. Started Zepbound in December and have lost 48lbs on it.

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Trelin21@reddit

Congrats partner!

gif

Why would you stop? I just use a very low dose every 2 weeks for maintenance.

Every medication we are put on for chronic health problems is a lifetime decision. Obesity is no different.

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BlueProcess@reddit

My remarks about stop/starting leading to decreased efficacy were based on this study, https://insight.jci.org/articles/view/205174

It is worth noting that this was on mice and so their hypothesis remains to be proven in humans.

That said, if what the study proposes is true, the implication would be that cycling the drug as you are suggesting might actually lead to receptors being desensitized over time and adaptive resistance.

However the counter argument would be that what is actually happening, happens after weight regain, hunger hormones rise, and the body defends regained weight more vigorously.

Which, if that is the underlying mechanism then cycling it would be a good strategy because it prevents the regain scenario.

The real truth remains to be seen and we will all get to hold hands and discover together. Which brings me back to my original assessment. It's a risk. If the risk if being on the medicine is outweighed by the risk of being off the medicine (which is my personal situation) then you have to decide which risk is most acceptable amd understand the risk that you are taking.

Which I think is generally consistent with Western Medical Practice. You educate on benefit, advise of risk, and let the patient make an informed decision to consent (or not).

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welltravelledRN@reddit

I’m not talking about stop/starting, not sure where you came up with that. I’m microdosing at a maintenance dose that works for me.

Your whole comment is irrelevant to what I said. You need to stay on medications that are for chronic conditions. You don’t stop antihypertensives because your BP is low on the med.

BizarroMax@reddit

Mounjaro. It’s been amazing.

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fluidentity@reddit

Same. 2years now, and lifelong medication for me due to metabolic hormone issues.

I’m literally half the person I used to be.

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BizarroMax@reddit

Consistent_Ice7857@reddit

yes, but be aware the online pricing has massive variations for similar products.

bil uses Onyx (glp-3) but technically it’s not for human use

spouse uses medvi (costs the most) but they have check-ins and a med professional assigned to you)

i use fifty410 (i get glp/gip) and buy option from a reputable compounding pharmacy

stay away from buying powdered peptides from china and mixing yourself

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Something_morepoetic@reddit

I am. I love it and do not plan to stop. It is life-saving.

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Yummy_Castoreum@reddit

I took Ozempic for a little while when my numbers tipped just over into "diabetic." It gave me incredible gut pain and I couldn't poop properly. I had to stop. (I'm on an elephantine dose of metformin now instead, but that lacks the happy side effect of weight loss, which I also need.) It doesn't help that I hate needles and had to have a friend shoot me up, lol.

Impressive_Star_3454@reddit

No.

5"7" was almost at 250lbs. I have an active job, but I dont get home until 730 pm which makes dinner impossible at that point.

I went to me internest when she asked about this.

I asked "Does it speed up my metabolism?"

No.

"Does it help my body digest food so the fat does not get absorbed?"

No.

"So, even if I take this I still have to be on a calorie deficit and exercise?"

Yes.

I am on a calorie deficit. I track my macros. I weight train. I am down to 235. Yes it is slow and I have to put in the work. It sucks tbh. But I'll be damned if I have to rely on taking a script for the rest of my life and then gain it back if I have to go off of it.

Yes I know I'm stubborn and stupid. Tell me something I don't know. Born that way.

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amazonchic2@reddit

GLP-1’s help you achieve a calorie deficit by making you feel full sooner and for longer. They help control your appetite. They also help slow digestion, so you don’t feel the desire to eat again as soon.

The idea is that they do these things so you can create better habits that will stick IF you decide to go off them. If you incorporate healthier eating and more physical activity while on them, you could (in theory) go off them and maintain that weight loss. You have to put in the same mental work as if you weren’t on GLP-1’s.

I use split and mirrored dosing and it’s eliminated all symptoms immediately!

I have always bought and used compounded glp1s, first from my obgyn and then switched to telemeds because it’s just a lot cheaper. I still follow the original advice from my doctor that got me started in terms of supplements and diet and exercise.

Same, girl!

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Roddy_Piper2000@reddit

Mounjaro. 55lb down. It will be a year in July.

Game changer for me.

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Long-Trade-9164@reddit

Same! Still struggle a bit with the nausea and slow bowel movements, but have dropped about 87 pounds total. Doctor first had me on Rybelsus and that was too slow of a process in losing the weight. I really struggled more with the nausea with that one. I didn't want to take the shot so opted for Rybelsus that's only in pill form.

Shockingly a lot of my aches and pains went away in my joints and lower back.

Also hair I take Spoiled Child & OMI to help with the shedding and diameter.

It sounds like a lot but I’m loading the issues - I want to have this even at a minimum as the pluses are amazing.

The upside is you only take 1x per week.

My late 70s mother is on it too and loves it. Both of us talked about the first blood test after you start it’s like our body went full reversal.

I am not a physician, just my experience and what worked for me so talk to your Dr and good luck!

Ps hard boiled eggs are the best if having a little nausea but need to eat.

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Mysterious_Can_6106@reddit

Would you elaborate more on what you’re taking for you hair? Wondering what you mean by diameter, I have super fine hair.. would this help with thinning.. I have noticed a lot of shedding but I noticed one spot thinner than others.. if I pull my hair back you can see my scalp in that area. My husband tells me it’s because I have gray roots so I can’t see the hair in that area.

lol, I hope my quarantine are understandable, I tried rewriting it but it still sounded crazy lol

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Suitable-Ad-1393@reddit

I have baby fine straight hair. So when you put your hair back in a ponytail and just holding it it seems maybe smaller like huh I thought I had more hair? It’s cause the diameter shrinks. Who knew?! But when you have such fine hair we can’t afford for it to get much smaller.

I take a product called Spoiled Child (I go on their site monthly subscription also avail on Amazon) it’s a liquid collagen so great for hair,nails, skin etc. I started getting growth.

OMI product is for that diameter seems my hair now isn’t shedding like it used to and when I pull my hair back it doesn’t feel small anymore. You can get OMI on Amazon, I get a discount for Subscribe and save.

Also Bamboo Extract can help but haven’t tried that one.

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stuck_behind_a_truck@reddit

I learned that I’m microdosing my Zepbound. 3mg twice a week for the long haul. For me it’s much less about losing weight and much more about the metabolic disorders caused by needing prednisone for several years while absolutely having the genes for T2D. I don’t need NAFLD turning into cirrhosis of the liver.

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whitebean@reddit

On Zepbound since January and lost 35 pounds, feel amazing and all my old clothes fit. Haven’t found a downside yet.

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MeatPopsicle_AMA@reddit

Started Zepbound 2 weeks ago, I’m down 13 pounds. Menopause/hysterectomy has really changed my body and I’m really fucking stoked to lose some weight after struggling to do so for a decade.

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redbeard914@reddit

I dropped from 287 to around 225 on GLP-1, over 8 months. I switched to TIRZ and dropped another 25 over about a year. I was working out (Treadmill & free weights) while losing weigh. My focus was on percent bodyfat, not so much a specific weight.

I lost another \~30 lbs for unrelated reasons. I am back on a very small amount TIRZ for maintenance (2.5 mg). I've been holding at 166-169 lbs since Oct last year. My PCP took me off my BP meds last week.

I am convinced that this is a genetic issue and the GLP-1/TIRZ drugs help with the issue.

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NoCup6161@reddit

Been on Tirzepatide (gray market) since December 2024. Down 65 pounds, high blood pressure gone, sleep apnea resolved, fatty liver disease gone. All blood tests, CT heart scan looks great. I now have a 23.7 BMI.

Best thing I ever did, been taking for 3 years

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Auferstehen78@reddit

I am on Mounjaro and have been since July. I lost 36lbs going from 212 down to 175.

Being diabetic type 2 to having a normal a1c.

This doesn't mean it's easy. I eat more protein and fiber to help keep full. Have learned to not eat everything on my plate.

There are times when I just stop eating whatever I am having because I actually am full.

I have increased my walking in the last two months going from an average of 3,000 to 7,000 steps a day plus some weight lifting.

I have another 40lbs to lose if I go by BMI because I am short.

Also, I have anemia and an undiagnosed inflammation or infection that causes me severe fatigue. And chronic migraines. So being able to exercise is hard, but I have managed getting on my walking pad every day for two months.

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Tired_o_Mods_BS@reddit

Seems to be an the rage for us 50 somethings. Starting to be hard to find people i know that aren't in them. I've resisted but i know it'll be good for me to drop the Lb's.

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mrekted@reddit

Sir, respectfully, I am 46, and I can gain/lose 50 pounds over a year pretty easily just with diet and exercise. Granted I'm a big guy, 6'4", and I'm doing it intentionally as part of a bulking cycle with weight training, but it's absolutely achievable without weight loss drugs.

Lost 50 pounds so far on Zepbound.

No side effects whatsoever, although of course YMMV.

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Beenthere-doneit55@reddit

I am soon to be 58M and I have always been a yo-yo weight gainer and loser. When I get motivated I can lose 10-15 lbs a month through diet and exercise. Problem is I gain it back. I had the gastric sleeve and lost 100 lbs and was about 20 lbs from my goal weight but gained about 40 back…honestly too much alcohol which is one way to get around the sleeve situation. I went on GLP-1 and it has been positive as I cannot overeat but I also stopped drinking so a mix of reasons. The combination of having a smaller stomach and the lack of appetite does make me feel strange at times but overall it’s been good. My two side effects are I am tired and feel a little bad when I do eat but that is probably just the little amount I consume. I also have very vivid dreams which I never had before and I have read that is a side effect. Other than that, I think it has been very positive. I wish it was around before I got the gastric sleeve because I would not have done that but too late.

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chicagoliz@reddit

My husband has been on Mounjaro for almost two years now and I'm astounded at what it's done for him. He's gone through periods of being heavy and thin, and even when he worked out every day and was thin, he always had asthma, including exercise induced asthma. For the 35 years I've known him, he always had to use his inhaler every day. After starting on Mounjaro, he used his inhaler about 4 times in the first year.

It got all his numbers in check and his weight is great. He's probably the healthiest he's ever been.

Yes. Fuck yes if you can take it.

I’ll address side effects in a moment.

BUT

You need to look at the whole picture. Besides a better diet and overall better nutrition, you should eat at set times and amounts. See a nutritionist.

Coupled with exercise. Which could be something simple as going for a walk for 15 minutes a day but you need to be moving. I saw a trainer to find a workout for me at my gym. Which has a pool I mostly use.

Finally the most important part is your behaviors. Taking the medication does work most excellently. If you go off of it but fall back into old patterns of bad eating. You’ll gain all the weight back. So you should talk to a behavioral therapist too.

I’ve been on Mounjaro for almost 3 years. I started at 245.8 lbs and last I checked a month ago I was 179. I’m 5’10” tall. I’m type 2 diabetic.

I haven’t weighed this little since high school. I haven’t needed additional insulin since the first year.

The side effects differ for all. I only had loose poop, poop farts at times. There are times food is gross. Which is both good and bad.

Some of the folks I know who started this medication type have experienced different reactions. One lady was mega constipated. She switched her dose to a lower amount and is doing fine. One person it did nothing at all for them. But most lost weight and being healthy has been their goal.

Check out the r/Mounjaro sub or whichever your doc suggested.

I take an injectable version. It’s nothing.

The worst part lately is being ambivalent about food. I am moving down to a lower dose after being maxed out for two years, that’s going on a maintenance level of the minimum needed to still get the benefits of the drug.

The biggest remedy of the drug is how it quiets the food noise.

It's been the best treatment for my T2D ever since I was diagnosed.

The way to manage the "Sulfur burps" is to drink lots of fluids. Because it slows down digestion, food in the stomach that is not submerged can begin to rot, which causes the sulfur. Drinking fluids keeps it submerged, (I learned this from a physician who did an interview on CBC Radio here in Canada)

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Enough-Cow-6869@reddit

Thank you!

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DPax_23@reddit

Last April I had a BMI of 37, it hurt to get up out of a chair, I got winded bending over to tie my shoes, and I had to rest during a mile walk.

Tirzepatide, a healthy macros structured diet, quadrupling my water intake, and a fuckload of lifting and cardio later and I'm in better shape than I was in my 20s.

Fast forward to now and I run 10 miles on Saturdays, run hill sprints on Tuesdays, and a threshold run on Thursdays. Plus I do casual runs twice more and lift 4 days a week. I've got 12.5% bodyfat right now and am in monster shape. Lean muscle rippling runners bod. I'm amazed by this every day still.

My doc talked to me about this medication and I blew him off for 6 months. That was a totally wasted 6 months out of a better, happier life.

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Mysterious_Can_6106@reddit

Started Victoza begging of Nov. lost 33 pounds. Couldn’t be happier.. have a few more to go than maintenance.

I do give myself a shot daily because Victoza is daily.. it is what my insurance covers. The needle is SO SMALL I don’t mind doing it daily. I also preferred daily because it didn’t seem like the side effects were as bad. Gosh the food noise was gone the morning after I took my first shot. It was/is amazing to get something from the fridge and not have whatever food scream my name until I ate it. Honestly I did not realize the food noise was as bad as it was until it was gone.

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Real-Emu507@reddit

Yes. But for chronic kidney disease.

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HatefulWithoutCoffee@reddit

Zepbound, up to 5mg. I've had virtually zero side effects. I discovered some serious health problems in my ancestors and needed to lose weight. A year ago I switched to 5 mg every 3 weeks, I can do every two weeks if I need it. My doctor supports this. I have nothing but good things to say about this medication. It has heart and inflammation properties that I appreciate as much as the weight loss.

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sophie1816@reddit

I was on a GLP1 and reached my goal weight. But when I went off it, I gained almost all of it back.

I was too chicken. I completely changed my diet and went to weight management center that was part of hospital system to get a nutrition plan created by dietitian with calorie intake for weight loss. I checked in regularly which provided accountability. Added exercise as I felt better. Took 15 months to drop 100 pounds. In maintenance mode for last 10 months and holding steady.

58 here. Tried 'em. Only needed to lose about 20 lbs.

They did not work for me.

Blocked me up like a cork. Didn't curb my appetite one iota and after 3 months, I GAINED 4 lbs.

Quit it, stopped eating like a teenager and started walking. Lost 23 lbs in 4 months and I'm as regular as Old Faithful, finally have my energy back and the doc tool me off my blood pressure meds.

Plus, I don't have the feeling the inside of my skin has been basted in lard, which I did have on them.

Of course, now I'm 647 miles from home. I should probably start walking back...

I'm going to guess you have high blood pressure, high cholesterol and joint pain at minimum now. Even if you only lose 10% of your body weight you'll see significant difference in all of those.

You also probably have sleep apnea and difficulty walking at a brisk pace or just walking in general for longer than a few minutes. Losing any amount of weight is going to improve those.

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Shockmaindave@reddit

235 to 191 like another poster. I also stopped drinking and it’s been great for my blood sugar control. I’ve been a type 1 diabetic since ‘76.

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mmconno@reddit

So grateful for tirzepatide (Zepbound). No side effects. It’s changed my life. I can now run 5ks without hurting my knees. My blood pressure is normal. I don’t obsess about food (the biggest thing for me). BMI down from 33 to 20.

Same!! I'm 51f and lost 40lbs on 7.5mg with no side effects effect hard stool, which Miralax helped with. I'm still on it, 10mg now, to maintain because the background noise of food is still present. My pms is still intense and I can't stop snacking and Zepbound helps with that.

Biblio-Kate@reddit

I’ve been on Zepbound since August 2025, and I’m down about 53 pounds. It’s a GLP-1 and GIP combination medication. The worst side effect I’ve had is mild constipation that is kept in check by increasing my water and fruit intake and some daily prunes.

It sounds exaggerated, but it really is a life-changing medicine. Along with the obvious weight loss benefits, it can help with inflammation, reduce the desire for alcohol, and silence food noise and other incessant thoughts. Of course, everyone has different experiences, but it’s worth trying.

I am self-pay and still on the lowest dose because it’s still working, so it’s about $300 per month. You might get lucky and have it be covered by insurance.

With the shots, I think, “Do I want some chocolate?” and one out of ten times I’ll answer, “Sure.” and eat one square of chocolate. The other nine times I think, “I don’t really need it,” and just have the popcorn.

If you do go on these, please OVER-HYDRATE! I walked behind a guy once who was telling his friend he really messed up his kidneys on them. A powerade zero every day, lower coffee intake, etc.

Good luck!

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Work4PSLF@reddit

Your angel/devil analogy - I have been saying something very similar since starting the med two years ago 😁

The med made dieting twice as effective as ever before, with half the suffering! Lost 97 lbs and maintaining for a year now.

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NightGod@reddit

I'm about eight months in and down from 235 to 191 as of this morning. Goal is about 165, decent chance I'll be there by the end of the year. Last time I was this light was literally last century. I know longer feel like I need to clean every plate I sit in front of me. Main side effect I had was some pretty evil heartburn the first six months, but a daily Pepcid took care of it. I realized a couple of months ago that I no longer needed it, so now my only side effect is losing weight

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williebgood@reddit

Lost 48 lbs on zepbound. Game changer. Also, not just weight success. My blood pressure is finally normal, I sleep better, and after my body gets used to less food, my energy has improved. I also feel so much more confident in wearing clothes and going out. ( going out = Friday night dinner with my husband and kids). But, it’s a game changer and I highly recommend.

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Cinnamon_heaven@reddit

I’m finally at a normal bmi for the first time in my life. Best thing was it stops the food noise. No cravings. Smaller portions. Wish I had done it sooner.

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gen_what_x_ever@reddit

Yes. I got diagnosed w/diabetes and was already overweight (fatttt) so I started taking Mounjaro. Switched to Zepbound (same med but cheaper for self-pay because my insurance won't cover it for any reason) and I've lost about 65 pounds since October. My A1c was normal after 3 months. I also started a low-dose statin at the same time because my entire lipid panel was fucked and everything on that was also normal after 3 months. I'm finally at a normal BMI as well.

Also I poop less, so I make sure to take myralax any day I don't poop.

You feel like you can never drink enough to stay hydrated.

blondvet@reddit

r/glp1

r/zepbound

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Reason_Training@reddit

Mounjaro has been life changing for my A1C. Haven’t lost much weight but my A1C is actually in a normal range.

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MVHood@reddit

Do it. I’m so much healthier after losing 70 lbs. I feel 10 years younger!

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blondvet@reddit

61 weeks on Zepbound. Life changing. I recommend it 100% if it’s something you’re willing to continue lifelong. It will make changes you’ve never even considered.

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TheFlannC@reddit

Zepbound for about the last 6 months. At my heaviest I weighed 310 lbs. I lost about 25 without now down an additional 30...just weighed in at 255

The worst side effect for me is diarrhea but have been able to manage it by taking metamucil

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Ecstatic-Move9990@reddit

Do it. I went from 178 to 130. Cholesterol normal now. No statins. More energy. Clothes fit better. Adds years to your life.

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newwriter365@reddit

debinprogress@reddit

Life changing medication. I have been on a diet my whole life and I’m finally making consistent progress in the right direction. It doesn’t do the work for you, but it makes it easier to do the things you need to do to lose weight/ get healthy.

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Thin_Ed3769@reddit

I’ve been taking it for a couple years now, for diabetes. Have lost and kept off around 50 lbs. Side effects have been minimal for me and my A1C now hovers at like 5.6. The biggest shift for me was mental, having to adjust to how much I could eat before I felt full, especially when ordering at a restaurant.

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johnbr@reddit

I'm 56, I take Zepbound, and it has worked really well for me. I've lost about 50 pounds over 18 months

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violet715@reddit

I’m 46. I feel like an entirely new woman. Even better than in my 30’s. I had less side effects on tirzepatide, for what it’s worth.

It’s amazing to be able to not think about food all the time, to feel confident in my clothes (and have fun with fashion again) and to be able to just work out moderately without trying to constantly kill myself to lose nothing.

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LizardJoeBiden@reddit

Grey market retatrutide here.

-80 lbs in 6 months. 304 in November. 222 this morning. 60 yo.

One BP med dropped, the other likely very soon.

Feel better then I have in a very very long time.

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Upper-Shoe-81@reddit

I’ve lost 41 pounds in 9 months and I’m finally back to a healthy weight for the first time since entering perimenopause. Some people get side effects, many don’t or they’re mild enough to handle. I had some body aches after my first two shots that lasted a couple days, then it was smooth sailing. Couldn’t be happier and highly recommend. I finally feel like “me” again.

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