nope doesnt matter at all. gen 5 ssd's will reach impressive sequential speed, might have more TBW and random IO, but realistically, for a game drive, even a SATA SSD is perfectly adequate and upgrading to a gen 4 NVME SSD would lower your loading times by a whole 3 seconds, which you will never feel, gen 5 is even less noticable.

QLC vs TLC is a lot more interesting discussion. Both drives will degrade rapidly once the SLC cache is exhausted, but it is far more drastic for QLC drives. But with PCIe gen4 or gen 5 speeds, your 5000 or 7500 Mbit/s drive will now do... 1500 Mbit/s instead, which is still pretty fast and more than enough for any use case besides copying 200 GB files around. QLC drives also have far lower TBW, but again, unless you are writing 200 GB a day, its unlikely you will hit those limits. I've had a 1 TB SATA SSD since 2020 that is currently on 112 TB of written data and its been my OS drive. Got 20 more years until i reach the 600 TBW.

DRAM has become far less important ever since HBM has become a thing and very few workloads benefit from a DRAM in a meaningful way now.

Realistically, nearly any SSD that performs predictably is entirely sufficient for everybody who isn't a video editor or something. I specifically call predictably because there are some weird SSDs, that really do behave randomly once the SLC cache is exhausted, which is more infuriating than knowing you are now on a perma 2000 mbit/s sequential speed.