Well first of all, you have to ride like a motorcyclist. That means you assume you are invisible to all larger vehicles on the road. You may often have the right of way only for a car to ignore your presence and barge on through. Cars coming out of driveways, waiting at stop signs, etc. will often proceed, ignoring a bike or motorcycle. I've ridden motorcycles since I was 10 and I've sort of developed an instinct for this behaviour.

Now second: Protective equipment is highly advised. It pretty much goes without saying that a helmet is a good thing (although I do hear people arguing about helmet use). Naturally a collision with a car will be disastrous helmet or not, but for many less-serious accidents a helmet can save you a head injury. Other protective items are a good idea also (gloves, knee and elbow pads, decent shoes). Wearing highly visible clothing is also recommended for obvious reasons. And light up your ebike. If you have bright lights on your ebike, cars are much more likely to notice you. This really applies mostly to night riding, but some lights are also visible in daylight. Another thing I recommend is a rear-view mirror. I like to see what's behind me just in case.

Lastly, use common sense. And choose routes that are safer, less-congested, and more bike-friendly.