RDS server - 64bit M365 Office with Access 2010 32bit

Posted by OCAU07@reddit | sysadmin | View on Reddit | 16 comments

We have a legacy application that needs 32 bit Access 2010 to run.

In 2024 we upgraded this sites infrastructure and installed Office O365ProPlusRetail 64bit using an XML built via the Office Deployment tool. We are using the MonthlyEnterprise update channel. I cannot recall doing this, but an older version of Access must have been installed to allow this legacy application to run.

Yesterday, in 2026 the legacy application stopped working. The old version of Access was removed and the directory path no longer exists. To get the site operational I found a copy of Access 2010 via our MSP and installed. Overnight it auto uninstalled.

I'm getting conflicting information on being able to run 64bit office with standalone older 32bit Access (installed via office Pro 2010 iso) on the same machine however it had been running for 2 years without issue.

I am assuming an update has uninstalled previous versions, any workaround to this potential issue that others have implemented?