Unlikely. Having watched LGRs videos on it and the Barbie PC they still need serious modification to accept anything bar the motherboard and power supply they were designed around. There's a slim chance a similarly dimensioned case exists (the hot wheels plastic is over an inner metal case) that might accept a different board but that's speculation.

However this is 2026, forget modding an original, even if it can be done don't bother. 3D print a clone case to slide over something like a shuttle PC or standard midi tower or just 3D print the whole thing, two colour printing is possible on many printers and there are all sorts of filaments to go with. That's the way to go, that way you can use any power supply, motherboard and cooling that you like.