Seriously. Skyler was reasonably pissed that Walt prioritized his ego over his family's reputation, safety, home, stability, and in Hank's case, his brother in law's life. He traumatized his entire surviving family and Albuquerque, ruined several lives, left Jesse to be enslaved by Nazis, with a swath of dead innocents, overdose victims.

All because he didn't want to accept money from Gretchen and Elliot, hundreds of people are dead (that we know of, probably more). 

He could've remained a teacher and beloved father, enjoyed a few more good years than he did, seen Holly grow up for a few years, seen Junior go off to college and helped him get a strong start to his education, and enjoyed the support and love of his family in his final days and left behind a good legacy as a brilliant educator and family man who was taken too soon. 

He could have even immigrated to Canada and as an exceptionally good chemical engineer responsible for Nobel Prize levels of work, had access to universal healthcare just months into his time there, and left his family a good amount of money by making a six figure income while he received treatment. 

Walt had a deluge of options that other people in his condition could only wish for, with only positive outcomes for him and the people who loved him most and the community around him. 

In short, Skyler is reasonably angry at Walt through every step of this, arguably not even angry enough.