Were you or your mum prescribed Debendox for morning sickness in the 70s/80s? Looking for families affected

Posted by Born-Impact-6339@reddit | AskUK | View on Reddit | 5 comments

my brother was born with trisomy 9 in 1981 after our mum was prescribed debendox (bendectin) for morning sickness. hes now 45 — one of the oldest known trisomy 9 survivors in the world. debendox was prescribed to millions of pregnant women in the 70s and 80s before being withdrawn. our family has always wondered whether there was a connection between the drug and marks chromosomal condition. were now doing whole genome sequencing on mark and researching whether debendox exposure could be linked to chromosomal abnormalities. this is a 50 year old mystery we finally have the tools to investigate. if you or your mother was prescribed debendox during pregnancy — especially if the child was born with any chromosomal condition — wed love to hear your story. contact: admin@helixsequencing.com or DM me more about marks story: helixsequencing.com/journal

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5 Comments

Kiss_It_Goodbyeee@reddit

Is this an attempt to drum up business?

exkingzog@reddit

IMO You are totally barking up the wrong tree here. If someone has trisomy this is the result of an error during meiosis to generate the gametes (egg or sperm). This will have happened well before any prescription of a morning-sickness medication. I can think of no plausible mechanism by which a drug could trigger trisomy in all cells of an individual later in gestation.

Voodoopulse@reddit

Isn't trisomy decided on fertilisation?

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