Is there a noticeable difference between the US states when traveling?

Posted by _Zouth@reddit | AskAnAmerican | View on Reddit | 343 comments

I've been on multiple roadtrips throughout Europe and of course there's quite a noticeable difference as soon as you cross a border, apart from language. Roads and roadsigns might look a bit different. Gas stations differs a bit etc. You immediately "feel" that you're in a different country without even leaving the highway or stepping out of the car. How noticeable is it in the US when you cross a state border, if at all?