I have a bunch of leftover PTO that I need to use. I can drive but prefer to fly to prevent the premature death of my poor little car. Starting from southern Ohio, where can I go for a weekend-sized trip?

I am big into architecture and good food. Don't have the stamina or the group to do a major national park, and I may get bored hiking by myself(or maybe not?) Feel free to suggest anything, though. Cannot leave the U.S., unfortunately.

I've been to all major cities east of the Mississippi except Minneapolis, Detroit, and Milwaukee. But I could revisit Chicago an infinite amount of times.