Custom loops are great for what they do but if you're the type of person to prefer a hands off experience you probably want to stick to an air cooled or AIO system. If you run into problems (blockage, corrosion, leaks) you may not have the luxury of waiting to bring your system over to Microcenter and need to deal with it right away. You also have to consider the eventual maintenance the system will require resulting in much longer down time (loop flushing, component cleaning, tubing replacement if soft tubing).

For most people the $500-$1000 you would spend going custom watercooling would be far better spent simply bumping your CPU/GPU up a few tiers.