Built a PC last weekend and I finally got Skyrim modded up to try with the native 32:9 support. I noticed in a pretty audible buzzing, even with the master volume off. The same is there in a different game, though to a lesser degree. It went away in menus, and when the computer is at idle, I don't hear the buzzing. BUT, if I turn the volume up on my studio monitors, there's a regular 'click' at about 1Hz.

I have an audio interface (Volt2) that I connected via USB, and that made the situation much worse. I tried the analog out through the front port and the back port, about the same volume level. The front port is definitely routed by the GPU and the power supply, but in my last case the cable literally sat on the PSU with no issues. As far as I can tell, the motherboard is seated well.

I've updated all my drivers, tried different cables. The only thing that gets rid of the noise is to plug my studio monitors into my monitor and get audio via display port, which makes it seem like there's some interference inside. The problem is my monitor audio output is really low, I'd have to crank the speakers which will jack up the levels I have on my work PC and phone for music.

Monitors are on the same electrical circuit and power strip as the PC. I know the power isn't the cleanest in our old house, but again - haven't had this issue in 8 years of living here on my old computer.

I haven't tried pulling everything out of the case yet because I just got everything in there :(

Are there any options to fix this short of pulling things out to try to reseat them or remove the IO panel to see if that's causing the interference? Do I just have a bum motherboard? Never had this issue with my last setup despite a more compact case.

MOBO: MSI Tomahawk B650 Wifi

GPU: 4070TI Super

Case: Be Quiet Shadow Base

PSU: Be Quiet Straight Power 12